Basic Traditional Chinese Medicinal Compound for Adjuvant Treatment of <i>Helicobacter pylori</i>-Related Gastritis: Implication for Anti-<i>H. pylori</i>-Related Gastritis Drug Discovery

This study was aimed at evaluating the efficacy of traditional Chinese medicine (TCM) in adjuvant treatment Helicobacter pylori-associated gastritis (HPAG) and exploring molecular mechanism underlying action basic TCM compounds against HPAG. Eight representative British databases were combed for pertinent literature. In light principle evidence-based medicine, this work rigorously stuck to inclusion exclusion criteria so as plump qualified articles. Also, data mining method adopted help determine compound HPAG treatment. Furthermore, a network pharmacology-based strategy used uncover mechanisms Ultimately, docking preliminary verification. combined with triple or quadruple therapy possessed more advantages improving total effective rate H. pylori eradication than alone. The plant materials consisted Citrus reticulata Blanco, Glycyrrhiza uralensis Fisch, Pinellia ternata (Thunb.) Breit, Coptis chinensis Franch, Poria cocos (Schw.) Wolf. Quercetin, kaempferol, naringenin, baicalein, nobiletin, hederagenin determined key active ingredients preparation Moreover, these played therapeutic role by acting on AKT1, TP53, interleukin (IL)-6, VEGFA, CASP3, MAPK3, JUN, TNF, MAPK8 via Pathways cancer, PI3K-Akt signaling pathway, TNF MAPK pathway. results indicated that could bind stably core targets. is worthy affirmation. Compatible use novel idea drug research profound clinical significance value development anti- drugs.